Phosphopeptides
Phosphopeptides play very important roles in cell signaling and may be self-antigens which may induce positive immune responses.
Researchers are showing increasing interests in phosphopeptides due to their broad applications in drug discovery for treating various kinds of diseases.
Phosphopeptides were initially synthesized by post phosphorylation of a synthesized peptide. However, low yields along with very strict reaction and purification conditions makes the synthetic method be a challenge. Fortunately, the introduction of monobenzyl protected phospho amino acids significantly improved the synthesis of phosphorpeptides with higher yields and purities. Furthermore, the monobenzyl phosphoric group is stable to the coupling/deprotecting conditions of Fmoc-SPPS, enabling the automated synthesis on a peptide synthesizer.
Advanced ChemTech carries various phospho amino acids which would meet the needs of your phosphopeptides synthesis.
FS2480: https://www.advancedchemtech.com/product/fmoc-serpoobzloh-oh/
FT2580: https://www.advancedchemtech.com/product/fmoc-thrpoobzloh-oh/
FY2580: https://www.advancedchemtech.com/product/fmoc-tyrpoobzloh-oh/
Teresa Shake Employee Spotlight
Why do you love to work at ACT?
I enjoy working at ACT because I am constantly learning new things. The company always strive to give the best customer experience and I enjoy being such an integral part of it. We are helping to create better lives for our customers and their customers.
How has the team at ACT motivated you in your role?
The team here is very supportive and helpful. Everything revolves around our customers and how we can make the biggest impact to their business. I diligently try to solve my customers concerns on a daily basis.
How does the mission and core values of ACT affect your job daily?
Our Mission is serving scientists and manufacturers by providing life science chemicals and equipment for drug discovery and manufacturing. Our values reflect this in everything we do as a company. All the employees believe wholeheartedly in the mission of this company.
What is your best success story?
I have so many its hard to say which is the best one. So many of our customers tell me on a daily basis how great we are to work with and that is a success in itself.
Do you have any passion projects?
My passion project right now is gardening. Currently I am trying my hand at raised garden beds at home. We have doubled our growing space and focusing on several varieties of hot peppers, tomatoes, greens, and herbs.
Picosecond electron transfer in peptides can help energy technologies
Biological energy flows, such as in photosynthesis and respiration, depend on the transfer of electrons from one molecule to another. Despite its importance to sustaining life, factors governing the rate of electron transfer, especially over long distances, are not well understood because the systems that mediate such ultrafast processes are very complex. A better understanding of electron transfer rates would help scientists improve chemical transformations, energy conversion, electronic devices, and photonic technologies.
Now, an international team of researchers led by UC Riverside has observed picosecond charge transfer mediated by hydrogen bonds in peptides. A picosecond is one trillionth of a second. As short-chain analogs of proteins, crucially important building blocks of living organisms, peptides are chains of chemically linked amino acids. The discovery shows the role of hydrogen bonds in electron transfer. The results are published in Proceedings of the National Academy of Sciences.
Valentine Vullev, a professor of bioengineering at UC Riverside’s Marlan and Rosemary Bourns College of Engineering, along with Daniel Gryko from the Polish Academy of Sciences, and Harry Gray from the California Institute of Technology, led a team that discovered unusually ultrafast electron transfer from a donor to an acceptor molecule connected with oligopeptide linkers stretching up to 20 covalent bonds. Electron transfer usually takes a microsecond, or one millionth of a second, in peptides with such long through-bond distances.
The researchers were surprised to observe picosecond electron transfer, a rate 1 million times faster than previously known for such systems.
“It shouldn’t work, but it does,” Vullev said. “The picosecond charge transfer we observed contradicts structural biology, assuming the expected random distribution of structures of the flexible peptide chains.”
The team chose donor and receptor molecules linked by short peptides they discovered actually assume well-defined structures stabilized by hydrogen bonds. Further analysis revealed that hydrogen bonds within each molecule brought the donor and acceptor close to each other in a scorpion-shaped molecular architecture, enabling picosecond electron transfer.
“This revolutionary design demonstrates short peptides can not only assume well-defined secondary conformations when templated by organic components but also provide a hydrogen-bonding network that can mediate electron transfer with unusually high efficiencies,” Vullev said. “Our work provides unprecedented paradigms for the design and development of charge-transfer pathways along flexible bridges, as well as insights into structural motifs for mediating electron transfer in proteins.”
The findings could lead to advances in energy storage as well as spur development of organic electronics that use conducting polymers instead of conducting minerals.
“One of the most exciting and fulfilling aspects about working in our group is being at the forefront of such discoveries and observing these spectacular results,” said co-author John Clark, a doctoral student in Vullev’s lab who did photochemical measurements for the research.
Story Source:
“Materials provided by University of
California – Riverside. Original written by Holly Ober. Note: Content may be edited for style and length.”
Journal Reference:
Rafał Orłowski, John A. Clark, James B. Derr, Eli M. Espinoza, Maximilian F. Mayther, Olga Staszewska-Krajewska, Jay R. Winkler, Hanna Jędrzejewska, Agnieszka Szumna, Harry B. Gray, Valentine I. Vullev, Daniel T. Gryko. Role of intramolecular hydrogen bonds in promoting electron flow through amino acid and oligopeptide conjugates. Proceedings of the National Academy of Sciences, 2021; 118 (11): e2026462118 DOI: 10.1073/pnas.2026462118
Buy of the Month : FK8110 / Fmoc-Lys(N3)-OH
Get 20% off when buying 5g
Trade shows for 2021 Will you be there?
Trade shows for 2021 Will you be there?
Many shows will be virtual but some you will be able to participate in person. This is a great opportunity to meet with your peers and discuss the most relevant news in your respective industries.
Join us!
Trade shows for 2021
- Pacifichem 2021: A Creative Vision for the Future
- 16th Dec 2021
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- 13th Dec 2021
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- 13th Dec 2021
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- 11th Dec 2021
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- 7th Dec 2021
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- 7th Dec 2021
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- 7th Dec 2021
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- 1st Dec 2021
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- 28th Nov 2021
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- 18th Nov 2021
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- 10th Nov 2021
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- 10th Oct 2021
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- 26th Sep 2021
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- 26th Sep 2021
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- 25th Sep 2021
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- 23rd Sep 2021
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- 20th Sep 2021
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- 19th Sep 2021
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- 1st Aug 2021
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The Tetras™
The Tetras™ is the only asynchronous multiple peptide instrument available today capable of performing independent peptide synthesis with variable scales, activations, lengths, and sequences.
- The Tetras™ provides versatility with ease of use and cost effectiveness by allowing the user the freedom to dictate the chemistry and by using low cost bulk chemicals and consumables.
- Modular design, almost zero downtime
- 32 digitally controlled metering pumps precisely deliver reagents and solvents
- Disposable, isolated reaction wells eliminate cross contamination
- Variable synthesis scale that can be run in parallel
- Remote access software, service engineer always beside you
- Flexible, user-defined protocols for each reaction well
- Flexibility and uncompromised reliability make the Tetras™ the instrument of choice for your peptide synthesis needs.
- Please follow the link to the website to view all details.