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Fmoc-Gln(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Gln [1]. Coupling can be performed by standard procedures. The trityl-protecting group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp. Using Fmoc-Gln(Trt)-OH in peptide synthesis prevents the possibility of the amide side chain from undergoing dehydration side reactions during activation, especially with carbodiimide reagents. Fmoc-Gln(Trt)-OH also has better solubility properties than Fmoc-Gln-OH. Fmoc-Gln(Trt)-OH dissolves readily in all standard peptide synthesis reagents, while Fmoc-Gln-OH is much less soluble in dimethylformamide (DMF).