2-Chlorotritylchloride Resin – An extremely versatile, acid-labile resin
Purchase Q83067785
View Safety Data Sheet (SDS)
| 5g | $40.00 |
| 25g | $145.00 |
| 100g | $445.00 |
"An extremely versatile, acid-labile resin for the solid phase immobilization of carboxylic acids, alcohols, phenols and amines, imidazoles and hydroxylamines. Release of these functionalities is generally achieved using 1-50% TFA in DCM containing 5% TIS, although carboxylic acids can also be cleaved from this support with AcOH/TFE/DCM, 0.5% TFA in DCM, or HFIP in DCM. 2-Chlorotrityl chloride resin can be cleaved under extremely mild acid conditions that leave Boc/tBu based protecting groups in place. Thus it is used to prepare protected peptide fragments. Amino acids can be attached to 2-Cl-Trt chloride resin with very little or no racemization. The steric bulk of 2-chlorotrityl chloride resin inhibits diketopiperazine formation, which can be a major side reaction in the synthesis of peptides with C-terminal proline." See prices below.
| Catalog Number | SC5055 |
| InChIKey | JFLSOKIMYBSASW-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)Cl |
| Chemical Formula | C₁₉H₁₄Cl₂ |
| PubChem CID | 94524 |
| DSSTOX Compound Identifier | DTXCID00117405 |
| Instance Of | type of chemical entity |
| DSSTox Substance ID | DTXSID60194914 |
| InChI | InChI=1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H |
| Mass | 313.221 |
| Subclass Of | chemical compound |
| CAS Registry Number | 42074-68-0 |
2-Chlorotritylchloride Resin – An extremely versatile, acid-labile resin
