Fmoc-Gln(Trt)-OH – Dissolves readily in peptide synthesis reagents

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Purchase Fmoc-Gln(Trt)-OH; Nalpha-Fmoc-Ndelta-trityl-L-glutamine; 132327-80-1

5g $25.00
25g $55.00
100g $165.00

Fmoc-Gln(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Gln [1]. Coupling can be performed by standard procedures. The trityl-protecting group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp. Using Fmoc-Gln(Trt)-OH in peptide synthesis prevents the possibility of the amide side chain from undergoing dehydration side reactions during activation, especially with carbodiimide reagents. Fmoc-Gln(Trt)-OH also has better solubility properties than Fmoc-Gln-OH. Fmoc-Gln(Trt)-OH dissolves readily in all standard peptide synthesis reagents, while Fmoc-Gln-OH is much less soluble in dimethylformamide (DMF). See prices below.

PubChem Compound Summary

Catalog Number FQ2251
Subclass Of chemical compound
UniChem Compound ID 24268718
CAS Registry Number 132327-80-1
Chemical Formula C₃₉H₃₄N₂O₅
EC Number 603-564-1
Mass 610.6991
PubChem CID 10919157
Isomeric SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)NC(=O)CC[C@@H](C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46
Canonical SMILES O=C(CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)NC(c1ccccc1)(c1ccccc1)c1ccccc1
InChIKey WDGICUODAOGOMO-DHUJRADRSA-N
InChI InChI=1S/C39H34N2O5/c42-36(41-39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29)25-24-35(37(43)44)40-38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34/h1-23,34-35H,24-26H2,(H,40,45)(H,41,42)(H,43,44)/t35-/m0/s1
ECHA Substance Infocard ID 100.109.682
DSSTox Substance ID DTXSID70448258
Instance Of type of chemical entity
DSSTOX Compound Identifier DTXCID70399079

Fmoc-Gln(Trt)-OH – Dissolves readily in peptide synthesis reagents

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Fmoc-Gln(Trt)-OH – Dissolves readily in peptide synthesis reagents Depositor-Supplied Synonyms

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Fmoc-Gln(Trt)-OH – Dissolves readily in peptide synthesis reagents R3D Conformer

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Fmoc-Gln(Trt)-OH – Dissolves readily in peptide synthesis reagents GHS Classification

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