OxymaPure – Non-explosive alternative to HOBt

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Purchase OxymaPure; Ethyl(hydroxyimino)cyanoacetate; Ethyl cyanohydroxyiminoacetate; 3849-21-6

5g $30.00
25g $70.00
100g $145.00

Ethyl cyanohydroxyiminoacetate (oxyma) is the oxime of ethyl cyanoacetate and finds use as an additive for carbodiimides, such as dicyclohexylcarbodiimide (DCC) in peptide synthesis. It acts as a neutralizing reagent for the basicity or nucleophilicity of the DCC due to its pronounced acidity (pKa 4.60) and suppresses base catalyzed side reactions, in particular racemization. OxymaPure®, an ideal additive used with carbodiimide coupling methodology, for amide bond formation. The 2-cyano-2-(hydroxyimino)acetate displays a remarkable capacity to suppress racemization and an impressive coupling efficiency in both automated and manual synthesis. OxymaPure® derived products are extensively adopted in pharmaceutical platform for the synthesis of various scaffolds such as Weinreb Amides; Oligobenzamides; ester bond formation and more. Oxyma Pure is a non-explosive alternative to HOBt. When used in place of HOBt in carbodiimide-mediated coupling reactions it provides products in higher yields with less racemization. OxymaPure® used with DIC produces peptides with increased yield and decreased epimerization when used as an alternative to HOBt.1 This safe, non-explosive auxiliary nucleophile works with carbodiimide coupling strategies to provide the best results for a peptide synthesis. Additionally, the use of DIC/Oxyma avoids side reactions associated with high levels of base (≥ 1 equiv. DIEA) using onium salt methods such as HBTU/DIEA. Highly soluble in peptide synthesis solvents. Extremely fast acylation rates. See prices below.

PubChem Compound Summary

Catalog Number RC8124
UniChem Compound ID 24083835
Instance Of type of chemical entity
Subclass Of chemical compound
Mass 142.1129
Chemical Formula C₅H₆N₂O₃
PubChem CID 6399078
CAS Registry Number 3849-21-6
Melting Point 130
InChI InChI=1S/C5H6N2O3/c1-2-10-5(8)4(3-6)7-9/h9H,2H2,1H3
UNII 2PHR89MH6P
Canonical SMILES CCOC(=O)C(=NO)C#N
InChIKey LCFXLZAXGXOXAP-UHFFFAOYSA-N

OxymaPure – Non-explosive alternative to HOBt

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OxymaPure – Non-explosive alternative to HOBt Depositor-Supplied Synonyms

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OxymaPure – Non-explosive alternative to HOBt R3D Conformer

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OxymaPure – Non-explosive alternative to HOBt GHS Classification

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Buy OxymaPure; Ethyl(hydroxyimino)cyanoacetate; Ethyl cyanohydroxyiminoacetate; 3849-21-6 online.