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"An extremely versatile, acid-labile resin for the solid phase immobilization of carboxylic acids, alcohols, phenols and amines, imidazoles and hydroxylamines. Release of these functionalities is generally achieved using 1-50% TFA in DCM containing 5% TIS, although carboxylic acids can also be cleaved from this support with AcOH/TFE/DCM, 0.5% TFA in DCM, or HFIP in DCM. 2-Chlorotrityl chloride resin can be cleaved under extremely mild acid conditions that leave Boc/tBu based protecting groups in place. Thus it is used to prepare protected peptide fragments. Amino acids can be attached to 2-Cl-Trt chloride resin with very little or no racemization. The steric bulk of 2-chlorotrityl chloride resin inhibits diketopiperazine formation, which can be a major side reaction in the synthesis of peptides with C-terminal proline."
